TREIT, Dallas
PhD, University of British Columbia
email: dtreit@ualberta.ca
THE
NEUROPSYCHOPHARMACOLOGY LAB:
PUBLICATIONS:
Yeung
M, Treit DR (2012). The anxiolytic effects of somatostatin following
intra-septal and intra-amygdalar microinfusions are reversed by the
selective
sst2 antagonist PRL2903. Pharmacology Biochemistry and Behavior
101:
88–92.
McEown
K, Treit DR (2011). Mineralocorticoid receptors in the medial
prefrontal cortex
and hippocampus mediate rats’ unconditioned fear behavior. Hormones and
Behavior 60:
581–588.
Yeung
M, Treit DR, Dickson CT (2011). A Critical Test of the Hippocampal
Theta Model
of Anxiolytic Drug Action. Neuropharmacology 62 : 155-160
McEown,
E., & Treit, D (2010). Inactivation of the dorsal or ventral
hippocampus with muscimol differentially affects fear and memory. Brain Research 1353, 145 151.
Engin
E, Treit D. (2009). Somatostatin SST-2 receptors mediate the
anxiolytic- and
antidepressant-like effects of somatostatin. Psychopharmacology,
206,
281-289.
Treit,
D., Engin, E., & McEown, K., (2009). "Animal Models of Anxiety and
Anxiolytic Drug Action".In: M. Stein & T. Steckler (Eds.) CTBN Behavioral Neurobiology of
Anxiety and its Treatment, Springer Verlag, in press.
McEown,
K., & Treit, D. (2009). The role of the dorsal and ventral
hippocampus in fear and memory of a shock-probe experience. Brain Research, 1251,
185-194.
Engin,
E., Stellbrink, J., Treit, D., & Dickson, C.T. (2008). Anxiolytic
and antidepressant effects of intracerebroventricularly administered
somatostatin: behavioral and neurophysiological evidence. Neuroscience, 157, 166-176.
Engin,
E., & Treit, D. (2008). Dissociation of the anxiolytic-like effects
of Avpr1a and Avpr1b receptor antagonists in the dorsal and ventral
hippocampus. Neuropeptides 42,
411–421.
Engin,
E., & Treit, D. (2008). The effects of intra-cerebral drug
infusions on animals' unconditioned fear reactions: A systematic
review. Progress in
Neuro-sychopharmacology & Biological Psychiatry, 32,
1399–1419.
Engin,
E., & Treit, D. (2007). The anxiolytic-like effects of
allopregnanolone vary as a function of intracerebral microinfusion
site: the amygdala, medial prefrontal cortex, or hippocampus. Behavioural Pharmacology, 18,
461–470.
Engin,
E., & Treit, D. (2007). The role of hippocampus in anxiety:
intracerebral infusion studies. Behavioural Pharmacology, 18,365–374.
Treit, D., & Pinel, J.P.J. (2005). “Defensive burying” In: I.Q. Wishaw and B. Kold (Eds.) The Behavior of the Laboratory Rat. New York : Oxford University Press, 353-362.
Shah, A.A., Sjovold, T., & Treit, D. (2004). Inactivation of the medial prefrontal cortex with the GABAA agonist muscimol increases open-arm activity in the elevated plus-maze and attenuates shock-probe burying in rats. Brain Research, 1028 , 112-115.
Shah, A.A., Sjovold, T., & Treit, D. (2004). Selective antagonism of medial prefrontal cortex D 4 receptors decreases fear-related behaviour in rats. European Journal of Neuroscience 19, 3393-3397.
Shah A.A., &Treit, D. (2004). Infusions of midazolam into the medial prefrontal cortex produce anxiolytic effects in the elevated plus-maze and shock-probe burying tests. Brain Research 996, 31-40.
Degroot A., &Treit, D. (2004). Anxiety is functionally segregated within the septo-hippocampal system. Brain Research 1001, 60-71.
Lehmann, H., Treit, D., & Parent M.B. (2003). Spared anterograde memory for shock-probe fear conditioning after inactivation of the amygdala. Learning and Memory 10, 261-269.
Degroot, A., & Treit, D. (2003). Septal GABAergic and hippocampal cholinergic systems interact in the modulation of anxiety. Neuroscience 117, 493-501.
Shah A.A., & Treit, D. (2003). Excitotoxic lesions of the medial prefrontal cortex attenuate fear responses in the elevated plus-maze, social interaction and shock probe burying test. Brain Research 696, 183-194.
Treit D., Degroot , A., & Shah, A. (2003). “Animal models of anxiety and anxiolytic drug action” In: S Kasper , J A den Boer and JMA Sitsen (Eds). Handbook of Depression and Anxiety, 2 nd edition. New York : Marcel Dekker, 681-702.
Degroot, A., & Treit, D. (2002). Dorsal and ventral hippocampal cholinergic systems modulate anxiety in the plus-maze and shock-probe tests. Brain Research 949, 60-70.
Degroot, A., & Treit, D. (2001). Septal GABAergic and hippocampal cholinergic systems modulate anxiety in the plus-maze and shock-probe tests. Pharmacology, Biochemistry, & Behavior 69, 391-399.
Treit, D., Degroot, A., Kashluba, S., & Bartoszyk, G. (2001). Systemic EMD 68843 injections reduce anxiety in the shock-probe, but not the plus-maze test. European Journal of Pharmacology 414, 245-248.
Menard, J., & Treit, D. (2001). The anxiolytic effects of intra-hippocampal midazolam are antagonized by intra-septal L-glutamate. Brain Research 888, 163-166.
Lehmann, H., Treit, D., & Parent, M. (2000). Amygdala lesions do not impair shock-probe avoidance retention performance. Behavioral Neuroscience 114, 107-116.
Menard, J., & Treit, D. (2000). Intra-septal infusions of excitatory amino acid receptor antagonists have differential effects in two animal models of anxiety. Behavioural Pharmacology 11, 99-108.
Treit, D., & Menard, J. (2000).The septum and anxiety. In R. Numan (Ed.), The Behavioral Neuroscience of the Septal Region, New York : Springer, 210-233.
Kalynchuk, L., Pinel, J., & Treit, D. (1999). Characterization of the defensive nature of kindling-induced emotionality. Behavioral Neuroscience 113, 766-775.
Menard, J., & Treit, D. (1999).Effects of centrally administered anxiolytic compounds in animal models of anxiety. Neuroscience and Biobehavioral Reviews 23, 591-613.
Treit, D., Aujla, H., & Menard, J. (1998). Does the bed nucleus of the stria terminalis mediate fear behaviors? Behavioral Neuroscience, 112, 379-386.
Menard, J., & Treit, D. (1998). The septum and the hippocampus differentially mediate anxiolytic effects of R(+)-8-OH-DPAT. Behavioural Pharmacology, 9, 93-101.
Fiorino, D., Treit, D., Menard, J., Lermer, L., & Phillips, A. (1998). Is barakol anxiolytic? Behavioural Pharmacology, 9, 375-378.
Kalynchuk, L., Pinel, J., & Treit, D. (1998). Long-term kindling and interictal emotionality in rats: effect of stimulation site. Brain Research, 779, 149-157.
Kalynchuk, L., Pinel, J., Treit, D., Barnes, S., McEachern, J., & Tippin, T. (1998). Persistence of the interictal emotionality produced by long-term amygdaloid kindling in rats. Neuroscience , 85 , 1311-1319.
Treit, D. & Menard, J. (1998). Animal models of anxiety and depression. In: Neuromethods: Vol. 32 In Vivo Neuromethods , A. Boulton, G. Baker, and A. Bateson (eds.), Totowa NJ, Humana Press, 89-148.
Pinel, J.P., Kalynchuk, L.E., & Treit D. (1998) Long-term amygdala kindling and defensive behavior in rats In: Kindling 5 V.M. Corcoran and S Moshel (eds.) New York, Plenum Press, 349-360.
Treit, D. & Menard, J. (1997). Dissociations among the anxiolytic effects of septal, hippocampal and amygdaloid lesions. Behavioral Neuroscience , 111 , 653-658.
Kalynchuk, L.E., Pinel, J.P., Treit, D., & Kippin T. (1997). Changes in Emotional Behavior produced by long-term amygdala kindling in rats. Biological Psychiatry , 41 , 438-451.
Pesold, C. & Treit D. (1996). The neuroanatomical specificity of the anxiolytic effects of intra-septal infusions of midazolam. Brain Research , 710 , 161-168.
Menard, J., & Treit, D. (1996). Lateral and medial septal lesions reduce anxiety in the plus-maze and probe-burying tests. Physiology and Behavior , 60 , 845-853.
Paslawski, T., Treit, D., Baker, G.B., George, M. & Coutts R.T. (1996). The antidepressant drug phenelzine produces antianxiety effects in the plus-maze and increases in rat brain GABA. Psychopharmacology , 127 , 19-24.
Menard, J. & Treit, D. (1996). Does Tolerance develop to the anxiolytic effects of septal lesions? Physiology and Behavior , 59 , 311-318.
Pesold, C. & Treit, D. (1995). The central and basolateral amygdala differentially mediate the anxiolytic effects of benzodiazepines. Brain Research 671, 213-221
Treit, D. Menard, J., & Pesold, C. (1994). The shock-probe burying test Neuroscience Protocols 94 , 1-9
Pesold, C. & Treit, D. (1994). The septum and amygdala differentially mediate the anxiolytic effects of benzodiazepines. Brain Research , 638 , 295-301.
Treit., D. (1994) Animal Models of anxiety and anxiolytic drug action In: J.A. den Boer and J.M. Ad Setsen (Eds.), Handbook of Depression and Anxiety , New York , Marcel Dekker, 201-224.
Treit, D. Pesold, C. & Rotzinger, S. (1993). Non-interactive effects of diazepam and amygdaloid lesions in two animal models of anxiety. Behavioral Neuroscience , 107 , 1099-1105.
Treit, D. Pesold. C. & Rotzinger, S. (1993). Dissociating the anti-fear effects of septal and amygdaloid lesions using two pharmacologically validated models of rat anxiety. Behavioral Neuroscience , 107 , 770-785.
Treit, D., Robinson, C. & Rotzinger, S. (1993). Anxiolytic effects of serotonergic intervensions in the shock-probe burying test and the elevated plus-maze test. Behavioural Brain Research , 54 , 23-34.
Treit, D., Menard, J., & Royan, C. (1993). Anxiogenic stimuli in the elevated plus-maze. Pharmacology Biochemistry and Behavior , 44 , 463-469.
Pesold, C. & Treit, D. (1992). Excitotoxic lesions of the septum produce anxiolytic effects in the elevated plus-maze and the shock-probe burying tests. Physiology and Behavior , 52 , 37-47.
Treit, D. (1991). A comparison of the effects of septal lesions and anxiolytic drugs on defensive behavior in rats. The Psychological Record , 41 , 217-231.
Treit, D. (1991). Defensive burying: a pharmacological animal model for specific fears. In: P. Soubrie, P. Simon, and D. Widlocher (Eds.), Animal Models of Psychiatric Disorders , Basal, Karger, 1-19.
Treit, D. (1991). Anxiolytic effects of benzodiazepine and 5-HT 1A agonists: Animal models. In: R.J. Rodgers and S.J. Cooper (Eds.), 5-HT 1A agonists, 5-HT3 antagonists and benzodiazepines: Their Comparative and Behavioural Pharmacology , New York , John Wiley, 107-131.
Treit, D. & Berridge, K. C. (1990). A comparison of benzodiazopine, serotonin, and dopamine agents in the taste-reactivity paradigm. Pharmacology Biochemistry & Behavior , 37 , 451-456.
Treit, D. (1990). A comparison of anxiolytic and non-anxiolytic agents in the shock-probe/burying test for anxiolytics. Pharmacology Biochemistry & Behavior , 36 , 203-205.
Treit, D., & Pesold, C. (1990). Septal lesions inhibit fear reactions in two animal models of anxiolytic drug action. Physiology & Behavior , 47 , 365-371.
Treit, D., & Fundytus, M. (1988). Thigmotaxis as a test for anxiolytic activity in rats. Pharmacology, Biochemistry & Behavior , 31 , 959-962.
Treit, D. & Fundytus, M. (1988). A comparison of buspirone and chlordiazepoxide in the shock-probe/burying test for anxiolytics. Pharmacology, Biochemisty & Behavior , 30 , 1071_1075.
Delamater, A.R. & Treit, D. (1988). Chlordiazepoxide attenuates shock-based and enhances LiCl-based fluid aversions. Learning & Motivation , 19 , 221-238
Berridge, K.C., Fentress, J.C., & Treit, D. (1988). A triggered hyperkinesia induced in rats by lesions of the corpus striatum. Experimental Neurology , 99 , 259-268.
Treit, D. (1987). Ro 15-1788, CGS 8216, Picrotoxin, pentylenetetrazol: Do they antagonize anxiolytic drug effects through an anxiogenic action? Brain Research Bulletin , 19 , 401-405.
Treit, D., Berridge, K.C. & Schultz, C.E. (1987). The direct enhancement of positive palatability by chlordiazepoxide is antagonized by Ro 15-1788 and CGS8216. Pharmacology, Biochemistry & Behavior , 26 , 709-714.
Treit, D., LoLordo, V.M. & Armstrong, E. (1986). The effects of diazepam on 'fear' reactions in rats are modulated by environmental constraints on the rat's defensive repertoire. Pharmacology, Biochemistry & Behavior , 25 , 561-565.
Treit, D. & Spetch, M.L. (1986). Caloric regulation in the rat: Control by two factors. Physiology & Behavior , 36 , 311-317.
Berridge, K.C. & Treit, D. (1986). Chlordiazepoxide directly enhances positive ingestive reactions in rats. Pharmacology, Biochemistry Behavior , 24 , 217-221.
Spetch, M.L. & Treit, D. (1986). Does effort play a role in the effect of response requirements on delayed matching to sample? Journal of the Experimental Analysis of Behavior , 45 , 19-31.
Treit, D. (1985). Animal models for the study of anti-anxiety agents: A review. Neuroscience & Biobehavioral Reviews , 9 , 203-222.
Treit, D. (1985). Evidence that tolerance develops to the anxiolytic effect of diazepam in rats. Pharmacology, Biochemistry & Behavior , 22 , 383-387.
Treit, D. (1985). The inhibitory effect of diazepam on defensive burying: Anxiolytic vs. Analgesic Effects. Pharmacology, Biochemistry & Behavior , 22 , 47-52.
Treit, D., Spetch, M.L. & Deutsch, J.A. (1984). Caloric regulation in the rat: Evidence for a calibration mechanism. Physiology & Behavior , 32 , 883-886.
Spetch, M.L. & Treit, D. (1984). The effect of d_amphetamine on short-term memory for time in pigeons. Pharmacology, Biochemistry, and Behavior , 21 , 663-666.
Treit, D. & Spetch, M.L. (1984). Effect of gastric reduction surgery on consummatory behavior in the rat. Behavioral Neuroscience , 98 , 361-365.
Treit, D., Spetch, M.L. & Deutsch, J.A. (1983). Variety in the flavor of food enhances eating in the rat. Physiology & Behavior , 30 , 207-211.
Pinel, J.P.J., & Treit, D. (1983). The conditioned defensive burying paradigm and behavioral neuroscience. In: T. Robinson (Ed.). Behavioral approaches to brain research , New York , Oxford University Press, 212-234.
Treit, D., Pinel, J.P.J., & Fibiger, H. (1982). The inhibitory effect of diazepam on conditioned defensive burying is reversed by picrotoxin. Pharmacology, Biochemistry, and Behavior , 17 , 359-361.
Treit, D., & Spetch, M.L. (1982). Advances toward a biological theory of aversive conditioning: Flirtation or commitment? (Commentary) The Behavioral and Brain Sciences , 5 , 684-685.
Spetch, M.L., Terlecki, L.J., Pinel, J.P.J., Wilkie, D.M., & Treit, D. (1982). Excitatory backward conditioning of defensive burying in rats. Bulletin of the Psychonomic Society , 19 , 111-114.
Treit, D., Pinel, J.P.J., & Fibiger, H. (1981). Conditioned defensive burying: A new paradigm for the study of anxiolytic agents. Pharmacology, Biochemistry, and Behavior , 15 , 619-626.
Gray, D., Terlecki, L.J., Treit, D., & Pinel, J.P.J. (1981). Effect of septal lesions on conditioned defensive burying. Physiology and Behavior , 27 , 1051-1056.
Treit, D., Terlecki, L.J., & Pinel, J.P.J. (1980). Conditioned defensive burying in rodents: Organismic variables. Bulletin of the Psychonomic Society , 16 , 451-454.
Treit, D., Terlecki, L.J., & Pinel, J.P.J. (1980). Active avoidance deficits after long-term exposure to ethanol: Associative or nonassociative effects. Substance and Alcohol Actions/Misuse , 1 , 165-172.
Treit, D., Pinel, J.P.J., & Terlecki, L.J. (1980). Shock intensity and conditioned defensive burying in rats. Bulletin of the Psychonomic Society , 16 , 5-7.
Pinel, J.P.J., Treit, D., Ladak, F., & Maclennan, J. (1980). Conditioned defensive burying in rats free to escape. Animal Learning Behavior , 8 , 447-451.
Pinel, J.P.J., Treit, D., & Wilkie, D.M. (1980). Stimulus control of defensive burying in the rat. Learning and Motivation , 11 , 150-163.
Terlecki, L.J., Pinel, J.P.J., & Treit, D. (1979). Conditioned and unconditioned defensive burying in the rat. Learning and Motivation , 10 , 337-350.
Pinel, J.P.J. & Treit, D. (1979). Conditioned defensive burying in the rat: Availability of burying materials. Animal Learning & Behavior , 7 , 392-396.
Pinel, J.P.J. & Treit, D. (1978). Burying as a defensive response in rats. Journal of Comparative and Physiological Psychology , 92 , 708-712.
Pinel, J.P.J., Treit, D., & Wilkie, D.M. (1977). Constraints on avoidance learning: Burying an unfounded assumption. In: S. Revusky (Ed.), Biological Approaches to Learning .
Pinel, J.P.J., Treit, D., & Rovner, L.I. (1977). Temporal lobe aggression in rats. Science , 197 , 1088-1089.
Pinel, J.P.J., Burtch, D., & Treit, D. (1976). Disulfiram implantation: Modes of action. Canadian Psychiatric Association Journal , 21 , 221-222.